SCHEMBL18508409

SCHEMBL18508409

Cc1ccc(Sc2nc(N(C)C)ccc2[N+](=O)[O-])cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 1/20 0.47
LMNA P02545 4/20 0.45
ALDH1A1 P00352 4/20 0.44
TXNRD1 Q16881 4/20 0.42
MAPT P10636 5/20 0.41
MEN1 O00255 3/20 0.41
KMT2A Q03164 3/20 0.41
HTT P42858 3/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
GFER P55789 1/20 0.40
PKM P14618 1/20 0.40
CYP3A4 P08684 1/20 0.39
TSHR P16473 1/20 0.39
ALOX12 P18054 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
POLB P06746 1/20 0.38
TDP1 Q9NUW8 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18508439 0.88 MEN1 (0.56) LMNATXNRD1MAPTMEN1KMT2A
SCHEMBL18508350 0.87 TXNRD1 (0.51) LMNAALDH1A1TXNRD1MAPTMEN1
SCHEMBL18508408 0.85 MERTK (0.43) IDO1ALDH1A1TXNRD1MAPTMEN1
SCHEMBL18508375 0.80 MEN1 (0.49) IDO1LMNAALDH1A1MAPTMEN1
SCHEMBL18497229 0.78 TXNRD1 (0.52) IDO1LMNAALDH1A1TXNRD1MAPT
SCHEMBL22205280 0.75 TXNRD1 (0.55) LMNAALDH1A1TXNRD1MAPTMEN1
SCHEMBL2066899 0.74 TXNRD1 (0.51) LMNAALDH1A1TXNRD1MAPTMEN1
SCHEMBL18508426 0.72 MEN1 (0.74) IDO1LMNAALDH1A1MAPTMEN1
SCHEMBL18508406 0.72 TXNRD1 (0.62) ALDH1A1TXNRD1MAPTMEN1KMT2A
SCHEMBL22264083 0.70 MEN1 (0.58) LMNAALDH1A1TXNRD1MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017027359-A1 PYRIDINES AND THEIR USE IN THE TREATMENT OF CANCER THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2017-02-16 WO disclosed