Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13131392 | 0.78 | REN (0.35) | HTR2AHTR2CHTR1ADRD2DRD4 | |
| SCHEMBL31728023 | 0.73 | CCR4 (0.39) | GAA | |
| SCHEMBL13132275 | 0.67 | REN (0.36) | — | |
| SCHEMBL18508622 | 0.67 | PHGDH (0.37) | HTR2AHTR2CHTR1ADRD2DRD4 | |
| SCHEMBL24252947 | 0.63 | NMT1 (0.37) | — | |
| SCHEMBL30791764 | 0.63 | NMT1 (0.37) | — | |
| SCHEMBL21649226 | 0.62 | MAPK8 (0.32) | — | |
| SCHEMBL21986190 | 0.61 | HTR2A (0.33) | HTR2AHTR2CHTR1ADRD2DRD4 | |
| SCHEMBL30092282 | 0.61 | HTR2A (0.33) | HTR2AHTR2CHTR1ADRD2DRD4 | |
| SCHEMBL1547496 | 0.61 | ALDH1A1 (0.45) | HTR2AHTR2CHTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |