Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL575848 | 0.84 | NPC1 (0.44) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL19719755 | 0.84 | MAPT (0.40) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL576144 | 0.84 | SLC6A4 (0.47) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL11064216 | 0.81 | ALOX15 (0.42) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL21205123 | 0.81 | MAPT (0.36) | MAPTMEN1KMT2ALMNATP53 | |
| Hydrochloric Acid SCHEMBL1013629 | 0.79 | SLC6A4 (0.47) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL12736249 | 0.79 | SLC6A4 (0.35) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL12736251 | 0.78 | SLC6A4 (0.36) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL13668477 | 0.78 | PDE3B (0.36) | MAPTMEN1KMT2ALMNATP53 | |
| SCHEMBL25457334 | 0.77 | DDR1 (0.45) | MAPTMEN1KMT2ALMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150587-B1 | DEUTERIUM SUBSTITUTED 1-[2-(2,4-DIMETHYL-THIOPHENYL)-PHENYL]PIPERAZINE COMPOUND OR DERIVATIVE THEREOF, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | JIANGSU JIBEIER PHARMACEUTICAL CO LTD (CN) | 2020-11-11 | — | — | EP | disclosed |
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |