Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL90116 | 0.81 | ALOX15 (0.39) | MAPTKDM4EUSP2TNKS2MEN1 | |
| SCHEMBL1229227 | 0.73 | REN (0.38) | MAPTKDM4EUSP2ALDH1A1MEN1 | |
| SCHEMBL3080203 | 0.72 | TSHR (0.44) | MAPTKDM4EUSP2ALDH1A1MEN1 | |
| SCHEMBL8265145 | 0.70 | PPARD (0.48) | MAPTKDM4EALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL3977247 | 0.70 | L3MBTL1 (0.41) | MAPTKDM4EUSP2ALDH1A1L3MBTL1 | |
| SCHEMBL7952850 | 0.69 | CYP3A4 (0.44) | ALDH1A1ALOX15TSHR | |
| SCHEMBL2810242 | 0.69 | REN (0.48) | MAPTKDM4EL3MBTL1 | |
| SCHEMBL29521379 | 0.69 | REN (0.48) | MAPTKDM4EL3MBTL1 | |
| SCHEMBL14666255 | 0.68 | TNKS2 (0.45) | MAPTTNKS2MEN1KMT2ATSHR | |
| SCHEMBL3071677 | 0.68 | CYP4F2 (0.54) | KDM4EALDH1A1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |