Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18084151 | 0.85 | HPGD (0.40) | HPGDERCC5FEN1MAOAMAOB | |
| SCHEMBL17265664 | 0.83 | HPGD (0.39) | HPGDERCC5FEN1MAOAMAOB | |
| SCHEMBL14887456 | 0.83 | MAOA (0.41) | HPGDERCC5FEN1MAOAMAOB | |
| SCHEMBL27427796 | 0.83 | MAOA (0.41) | HPGDERCC5FEN1MAOAMAOB | |
| SCHEMBL13957399 | 0.83 | HPGD (0.41) | HPGDERCC5FEN1MAOAMAOB | |
| SCHEMBL20879355 | 0.81 | MAOA (0.42) | HPGDERCC5FEN1MAOAMAOB | |
| SCHEMBL18084165 | 0.80 | NPC1 (0.45) | HPGDTSHRALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10580663 | 0.80 | NPC1 (0.45) | HPGDTSHRALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7947843 | 0.79 | HPGD (0.47) | HPGDERCC5FEN1TSHRMAPK1 | |
| SCHEMBL15250257 | 0.77 | MAPT (0.43) | HPGDTSHRALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |