Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29119395 | 0.84 | ALDH1A1 (0.52) | HPGDKMT2ATSHRALDH1A1KDM4E | |
| SCHEMBL29119429 | 0.84 | KDM4E (0.50) | HPGDKMT2ATSHRALDH1A1KDM4E | |
| SCHEMBL9510857 | 0.81 | HPGD (0.47) | HPGDKMT2AALDH1A1KDM4ECYP1A2 | |
| SCHEMBL18508975 | 0.79 | HPGD (0.41) | HPGDKMT2AERCC5FEN1TSHR | |
| SCHEMBL7955212 | 0.78 | ALDH1A1 (0.38) | TSHRALDH1A1KDM4ECYP1A2CYP2C19 | |
| SCHEMBL2303277 | 0.77 | PDPK1 (0.51) | HPGDKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL2303273 | 0.77 | PDPK1 (0.51) | HPGDKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6515252 | 0.77 | PDPK1 (0.51) | HPGDKMT2AKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL18084151 | 0.77 | HPGD (0.40) | HPGDKMT2AERCC5FEN1TSHR | |
| SCHEMBL8949240 | 0.76 | TSHR (0.50) | HPGDKMT2AERCC5FEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211197-B1 | CARBOXYLIC ACID OR TETRAZOLE DERIVATES; ANALGESICS, ANTIPYRETICS, AND ANTIINFLAMMATORY AGENTS; SIDE EFFECT REDUCTION | MERCK FROSST CANADA & CO. (CA) | 2001-04-03 | — | — | US | disclosed |