Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18508975 | 0.85 | HPGD (0.41) | HPGDF2RALDH1A1KMT2ANPC1 | |
| SCHEMBL27427796 | 0.82 | MAOA (0.41) | HPGDF2RALDH1A1KMT2ANPC1 | |
| SCHEMBL17265664 | 0.82 | HPGD (0.39) | HPGDF2RALDH1A1KMT2ANPC1 | |
| SCHEMBL14887456 | 0.82 | MAOA (0.41) | HPGDALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL7947843 | 0.77 | HPGD (0.47) | HPGDALDH1A1KMT2ANPC1RAB9A | |
| SCHEMBL2119445 | 0.73 | ERCC5 (0.44) | HPGDKMT2AERCC5FEN1SMN1; SMN2 | |
| SCHEMBL5011123 | 0.73 | ERCC5 (0.44) | HPGDALDH1A1KMT2AERCC5FEN1 | |
| SCHEMBL13957399 | 0.72 | HPGD (0.41) | HPGDALDH1A1KMT2AL3MBTL1ERCC5 | |
| SCHEMBL24832677 | 0.71 | HPGD (0.44) | HPGDALDH1A1KMT2AERCC5FEN1 | |
| SCHEMBL16257948 | 0.71 | TSHR (0.41) | HPGDERCC5FEN1SMN1; SMN2MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9434761-B2 | Tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2016-09-06 | — | — | US | disclosed |