Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852418 | 0.80 | HPGD (0.53) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL1850316 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL1850906 | 0.74 | HPGD (0.58) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL1851522 | 0.73 | MAPT (0.57) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL4431903 | 0.73 | ALDH1A1 (0.42) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL1852416 | 0.73 | HPGD (0.58) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL4125534 | 0.71 | HPGD (0.55) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL1855922 | 0.70 | RAB9A (0.43) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL1848031 | 0.70 | KDM4E (0.46) | ALDH1A1HPGDKMT2AHSD17B10KDM4E | |
| SCHEMBL1857370 | 0.69 | KMT2A (0.54) | ALDH1A1HPGDKMT2AHSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-B1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS INC (US) | 2011-05-25 | — | — | EP | disclosed |