Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | REN | P00797 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13132277 | 0.93 | REN (0.46) | HSD11B1RENNR1H4HRH1ADRA1A | |
| SCHEMBL18509079 | 0.91 | REN (0.40) | HSD11B1RENNR1H4HTR2CSLC6A4 | |
| SCHEMBL2834678 | 0.85 | REN (0.49) | HSD11B1RENNR1H4HRH1ADRA1A | |
| SCHEMBL2833986 | 0.82 | REN (0.51) | RENHRH1ADRA1AADRA1BCYP3A4 | |
| SCHEMBL13448648 | 0.80 | REN (0.45) | RENHRH1ADRA1AADRA1BHRH3 | |
| SCHEMBL27795799 | 0.79 | TSHR (0.43) | HSD11B1RENNR1H4HTR2CSLC6A4 | |
| SCHEMBL13132274 | 0.78 | REN (0.41) | RENNR1H4 | |
| SCHEMBL13132300 | 0.78 | REN (0.40) | HSD11B1RENNR1H4HTR2CSLC6A4 | |
| SCHEMBL13132696 | 0.77 | REN (0.51) | RENJAK2JAK1 | |
| SCHEMBL2810132 | 0.77 | REN (0.41) | RENNR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-B1 | MORPHOLINE DERIVATIVES AS RENIN INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2017-02-15 | — | — | EP | disclosed |