Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27774894 | 0.86 | KDM1A (0.36) | TSHRHPGDMAPTHSD11B1REN | |
| SCHEMBL27795796 | 0.86 | SLC22A12 (0.38) | HSD11B1RENNR1H4CETP | |
| SCHEMBL13132300 | 0.80 | REN (0.40) | HSD11B1RENNR1H4HTR2CSLC6A4 | |
| SCHEMBL13132277 | 0.80 | REN (0.46) | HSD11B1RENNR1H4 | |
| SCHEMBL2834678 | 0.79 | REN (0.49) | HSD11B1RENNR1H4 | |
| SCHEMBL13132274 | 0.79 | REN (0.41) | RENNR1H4 | |
| Hydrochloric Acid SCHEMBL27774966 | 0.79 | TSHR (0.47) | TSHRKDM4EHSD17B10KMT2AALDH1A1 | |
| SCHEMBL18509080 | 0.79 | HSD11B1 (0.39) | TSHRHSD11B1RENNR1H4CETP | |
| SCHEMBL2810132 | 0.77 | REN (0.41) | RENNR1H4 | |
| SCHEMBL18509079 | 0.77 | REN (0.40) | HSD11B1RENNR1H4CETPHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679324-B | Morpholine derivatives | MITSUBISHI TANABE PHARMA CORP | 2012-10-03 | — | — | CN | disclosed |
| CN-101679324-A | Morpholine derivatives | MITSUBISHI TANABE PHARMA CORP | 2010-03-24 | — | — | CN | disclosed |