Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 13/20 | 0.45 |
| ▸ | HRH1 | P35367 | 6/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2833986 | 0.88 | REN (0.51) | RENHRH1KCNH2ADRA1AADRA1B | |
| SCHEMBL13132277 | 0.87 | REN (0.46) | RENHRH1KCNH2ADRA1AADRA1B | |
| SCHEMBL18509079 | 0.81 | REN (0.40) | RENHRH1KCNH2ADRA1AADRA1B | |
| SCHEMBL2834678 | 0.80 | REN (0.49) | RENHRH1ADRA1AADRA1B | |
| SCHEMBL18509080 | 0.80 | HSD11B1 (0.39) | RENHRH1ADRA1AADRA1BCYP3A4 | |
| SCHEMBL13131580 | 0.79 | REN (0.74) | REN | |
| SCHEMBL13448686 | 0.76 | SLC22A12 (0.35) | RENITK | |
| SCHEMBL13132696 | 0.75 | REN (0.51) | REN | |
| SCHEMBL2808527 | 0.75 | REN (0.46) | RENITK | |
| SCHEMBL13132383 | 0.74 | HRH1 (0.38) | RENHRH1KCNH2ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168952-A1 | MORPHOLINE DERIVATIVE | Mitsubishi Tanabe Pharma Corporation (JP) | 2010-03-31 | — | — | EP | disclosed |