Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9571891 | 0.78 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| SCHEMBL3774606 | 0.76 | LMNA (0.42) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| SCHEMBL3774666 | 0.76 | LMNA (0.42) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| SCHEMBL16882299 | 0.76 | LMNA (0.42) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| SCHEMBL9571890 | 0.73 | SMN1; SMN2 (0.43) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| SCHEMBL2787464 | 0.72 | SMN1; SMN2 (0.41) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| SCHEMBL5355515 | 0.71 | LMNA (0.50) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| SCHEMBL7073674 | 0.69 | ALDH1A1 (0.41) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| Fluoride SCHEMBL29068332 | 0.69 | ALDH1A1 (0.64) | LMNASMN1; SMN2POLBALDH1A1ATM | |
| SCHEMBL9571887 | 0.68 | LMNA (0.36) | LMNASMN1; SMN2POLBALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |