Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | P2RY11 | Q96G91 | 1/20 | 0.40 |
| ▸ | SLC29A1 | Q99808 | 5/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.37 |
| ▸ | LGALS9 | O00182 | 1/20 | 0.37 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.37 |
| ▸ | LGALS3 | P17931 | 1/20 | 0.37 |
| ▸ | LGALS7; LGALS7B | P47929 | 1/20 | 0.37 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17202905 | 0.93 | LMNA (0.49) | LMNAADORA2AADORA3ADORA1P2RY11 | |
| SCHEMBL18512571 | 0.89 | LMNA (0.46) | LMNAADORA2AADORA3ADORA1P2RY11 | |
| SCHEMBL18512585 | 0.86 | LMNA (0.43) | LMNAADORA2AADORA3ADORA1P2RY11 | |
| SCHEMBL18512581 | 0.86 | NT5E (0.45) | LMNAP2RY11P2RX3P2RX4P2RX2 | |
| SCHEMBL17202720 | 0.83 | LMNA (0.49) | LMNAADORA2AADORA3ADORA1P2RY11 | |
| SCHEMBL23566752 | 0.82 | LMNA (0.47) | LMNAADORA2AADORA3ADORA1P2RY11 | |
| SCHEMBL18512597 | 0.81 | LMNA (0.62) | LMNAADORA2AP2RY11SLC29A1P2RX3 | |
| SCHEMBL16203604 | 0.81 | LMNA (0.62) | LMNAADORA2AP2RY11SLC29A1P2RX3 | |
| SCHEMBL17677178 | 0.80 | LMNA (0.64) | LMNAADORA2AP2RY11SLC29A1P2RX3 | |
| SCHEMBL29672354 | 0.80 | LMNA (0.64) | LMNAADORA2AP2RY11SLC29A1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170044203-A1 | PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044203-A1 | PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER | ENTPD5, ENTPD1, NT5E | LMNA 2579/4885ADORA2A 12/4885ADORA3 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.