Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.44 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.44 |
| ▸ | P2RY11 | Q96G91 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | P2RX6 | O15547 | 1/20 | 0.36 |
| ▸ | P2RX5 | Q93086 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18512571 | 0.94 | LMNA (0.46) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL17202905 | 0.88 | LMNA (0.49) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL17203004 | 0.84 | LMNA (0.43) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL18493316 | 0.84 | LMNA (0.43) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL23566761 | 0.84 | LMNA (0.43) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL18512580 | 0.82 | LMNA (0.48) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL17213521 | 0.82 | LMNA (0.44) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL13769463 | 0.82 | LMNA (0.59) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL13864334 | 0.80 | LMNA (0.56) | LMNAP2RX3P2RX4P2RX2P2RY11 | |
| SCHEMBL13046077 | 0.80 | LMNA (0.60) | LMNAP2RX3P2RX4P2RX2P2RY11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134411-B1 | PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INT (DE) | 2021-06-30 | — | — | EP | disclosed |