Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.38 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27668674 | 0.85 | RAB9A (0.48) | ADRA2AADRA2BADRA2CMAPTRAB9A | |
| SCHEMBL19716497 | 0.83 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CMAPTRAB9A | |
| SCHEMBL29658558 | 0.83 | ADRA2A (0.43) | ADRA2AADRA2BADRA2CMAPTRAB9A | |
| SCHEMBL31240136 | 0.83 | MAPT (0.43) | ADRA2AADRA2BADRA2CMAPTRAB9A | |
| SCHEMBL29457073 | 0.80 | EPHX1 (0.42) | MAPTRAB9AEPHX1KDM4EMEN1 | |
| SCHEMBL29457012 | 0.80 | APLNR (0.54) | HDAC6EPHX1APLNR | |
| SCHEMBL29457086 | 0.80 | PTK2 (0.42) | ADRA2AADRA2BADRA2CRAB9APLAU | |
| SCHEMBL17827994 | 0.79 | RAB9A (0.43) | MAPTRAB9ACCR1CCR5CCR8 | |
| SCHEMBL1852826 | 0.77 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CMAPTRAB9A | |
| SCHEMBL19738832 | 0.77 | CACNA1I (0.46) | ALOX5ALDH1A1KDM4EPARP1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324028-A2 | THERAPEUTIC AGENTS 414 | AstraZeneca AB (SE) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010015849-A2 | THERAPEUTIC AGENTS 414 | ASTRAZENECA AB (SE) | 2010-02-11 | — | — | WO | disclosed |