Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | OGT | O15294 | 1/20 | 0.32 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.31 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3966457 | 0.79 | NOS1 (0.39) | KMONOS1NOS3NOS2LMNA | |
| SCHEMBL10884762 | 0.78 | KMO (0.50) | KMONOS1NOS3NOS2LMNA | |
| SCHEMBL15319641 | 0.75 | KMO (0.47) | KMONOS1NOS3NOS2LMNA | |
| SCHEMBL5547929 | 0.75 | NOS1 (0.49) | KMONOS1NOS3NOS2LMNA | |
| SCHEMBL5547925 | 0.75 | KMO (0.47) | KMONOS1NOS3NOS2LMNA | |
| SCHEMBL1121813 | 0.72 | ALDH1A1 (0.43) | LMNACYP1A2TSHRNPSR1ALDH1A1 | |
| SCHEMBL10884377 | 0.71 | KMO (0.55) | KMONOS1NOS3NOS2LMNA | |
| SCHEMBL3600957 | 0.68 | NOS1 (0.58) | KMONOS1NOS3NOS2LMNA | |
| Hydrochloric Acid SCHEMBL6426764 | 0.68 | KMO (0.40) | KMONOS1NOS3NOS2LMNA | |
| SCHEMBL5078162 | 0.68 | ALDH1A1 (0.58) | KMONOS1NOS3NOS2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3130583-A1 | KYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF | CHDI Foundation, Inc. (US) | 2017-02-15 | — | — | EP | disclosed |