Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 6/20 | 0.64 |
| ▸ | NT5E | P21589 | 1/20 | 0.59 |
| ▸ | GSK3A | P49840 | 2/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | PNP | P00491 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.55 |
| ▸ | TGM2 | P21980 | 1/20 | 0.55 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.51 |
| ▸ | KRAS | P01116 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.49 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138984 | 0.91 | HINT1 (0.75) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL4540753 | 0.90 | HINT1 (0.63) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL1737322 | 0.86 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL6748870 | 0.86 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL1737326 | 0.86 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL25381419 | 0.86 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL1737325 | 0.86 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL8164012 | 0.86 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL20434874 | 0.86 | HPGD (0.62) | HINT1NT5EGSK3ARPS6KA3MAPK14 | |
| SCHEMBL26622652 | 0.86 | HINT1 (0.63) | HINT1NT5EGSK3ARPS6KA3MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027646-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-02-16 | — | — | WO | disclosed |