Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.42 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 3/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 3/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17206300 | 0.81 | CNR2 (0.42) | KCNQ3KCNQ2KCNQ4KCNQ5ALDH1A1 | |
| SCHEMBL17206332 | 0.75 | TAS1R3 (0.58) | ALDH1A1HPGDNPC1TAS1R3TAS1R1 | |
| SCHEMBL17205222 | 0.75 | TAS1R3 (0.58) | ALDH1A1HPGDNPC1TAS1R3TAS1R1 | |
| SCHEMBL17209758 | 0.71 | NR4A2 (0.41) | KDM4EALDH1A1HSD17B10NPC1MAPT | |
| SCHEMBL17206324 | 0.71 | CNR2 (0.56) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL18183293 | 0.70 | KCNQ3 (0.32) | KCNQ3KCNQ2KCNQ4KCNQ5NPC1 | |
| SCHEMBL17209765 | 0.66 | KDM4E (0.47) | KDM4EHSD17B10LMNAMAPTRAB9A | |
| SCHEMBL17205524 | 0.66 | KDM4E (0.46) | KDM4EMAPT | |
| SCHEMBL13638925 | 0.64 | HSD17B10 (0.70) | KDM4EALDH1A1HSD17B10HPGDTSHR | |
| SCHEMBL17205197 | 0.62 | TAS1R3 (0.45) | KCNQ3KCNQ2KCNQ4KCNQ5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170044100-A1 | INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS | UNIV JOHNS HOPKINS (US) | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044100-A1 | INHIBITORS OF DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS | IDO2, IDO1, INMT | KCNQ3 3862/4885KCNQ2 3582/4885KCNQ4 3988/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.