Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.57 |
| ▸ | RAB9A | P51151 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | GLA | P06280 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18523537 | 1.00 | NPC1 (0.57) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18533724 | 0.89 | NPC1 (0.62) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL20473367 | 0.88 | NPC1 (0.60) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18533683 | 0.87 | NPC1 (0.58) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL23316864 | 0.87 | NPC1 (0.59) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL20473133 | 0.85 | SIGMAR1 (0.42) | ACHEBCHE | |
| SCHEMBL18523584 | 0.85 | MAOB (0.48) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18523585 | 0.85 | MAOB (0.48) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL22569369 | 0.79 | NPC1 (0.61) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18583503 | 0.76 | MAOB (0.52) | NPC1RAB9AKDM4EGLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11111226-B2 | Hydrophilic compounds for optically active devices | MERCK PATENT GMBH (DE) | 2021-09-07 | — | — | US | disclosed |
| EP-3337794-B1 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2021-07-21 | — | — | EP | disclosed |
| US-20200262805-A1 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2020-08-20 | — | — | US | disclosed |
| US-10723713-B2 | Hydrophilic compounds for optically active devices | MERCK PATENT GMBH (DE) | 2020-07-28 | — | — | US | disclosed |
| US-20180237410-A1 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2018-08-23 | — | — | US | disclosed |
| EP-3337794-A1 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | Merck Patent GmbH (DE) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017032444-A1 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2017-03-02 | — | — | WO | disclosed |
| EP-3133066-A1 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11111226-B2 | Hydrophilic compounds for optically active devices | AQP1, AQP3, AQP4 | NPC1 2773/4885RAB9A 2065/4885KDM4E 4586/4885 |
| US-20200262805-A1 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | AQP1, AQP3, AQP4 | NPC1 2773/4885RAB9A 2065/4885KDM4E 4586/4885 |
| US-10723713-B2 | Hydrophilic compounds for optically active devices | AQP1, AQP3, AQP4 | NPC1 2773/4885RAB9A 2065/4885KDM4E 4586/4885 |
| US-20180237410-A1 | HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | AQP1, AQP3, AQP4 | NPC1 2773/4885RAB9A 2065/4885KDM4E 4586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.