Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | CTSV | O60911 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894604 | 0.79 | ALDH1A1 (0.45) | ALDH1A1HSD17B10HPGDKDM4ECTSV | |
| SCHEMBL5042737 | 0.78 | CTSV (0.58) | ALDH1A1HSD17B10HPGDKDM4ECTSV | |
| SCHEMBL24983869 | 0.76 | LMNA (0.56) | HPGDKDM4ECTSVCTSLLMNA | |
| SCHEMBL18497772 | 0.76 | HPGD (0.53) | ALDH1A1HSD17B10HPGDKDM4ECYP1A2 | |
| SCHEMBL21327288 | 0.76 | LMNA (0.52) | HPGDCTSVCTSLMAPTLMNA | |
| SCHEMBL16491116 | 0.73 | USP2 (0.43) | ALDH1A1HSD17B10HPGDCTSVCTSL | |
| SCHEMBL11565369 | 0.73 | LRRK2 (0.59) | ALDH1A1HPGDKDM4ECTSVCTSL | |
| SCHEMBL384872 | 0.73 | MAOB (0.56) | HPGDKDM4ECTSVCTSLMAPT | |
| SCHEMBL11563262 | 0.73 | MAOB (0.56) | ALDH1A1HPGDKDM4ECTSVCTSL | |
| SCHEMBL167312 | 0.72 | LMNA (0.49) | ALDH1A1HPGDKDM4ECYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017025849-A1 | BICYCLIC-FUSED HETEROARYL OR ARYL COMPOUNDS | PFIZER INC. (US) | 2017-02-16 | — | — | WO | disclosed |