Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | PRKACA | P17612 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30522124 | 1.00 | GAA (0.56) | GAAPDPK1ROCK1CDK5CLK4 | |
| SCHEMBL16680793 | 0.85 | KDR (0.56) | GAAPDPK1ROCK1CDK5CLK4 | |
| SCHEMBL16681210 | 0.81 | ROCK1 (0.67) | GAAPDPK1ROCK1CDK5CLK4 | |
| SCHEMBL16680735 | 0.81 | CLK4 (0.63) | GAAPDPK1ROCK1CDK5CLK4 | |
| SCHEMBL1960297 | 0.80 | HTR2A (0.51) | GAAMAPK8HTR2ATTKKEAP1 | |
| SCHEMBL2995256 | 0.80 | HTR2A (0.51) | MAPK8HTR2ATTKKDM4EKEAP1 | |
| SCHEMBL215191 | 0.79 | NPC1 (0.58) | GAAPDPK1ROCK1CDK5CLK4 | |
| SCHEMBL30548031 | 0.79 | HTR2A (0.50) | MAPK8HTR2ATTKKDM4EKEAP1 | |
| SCHEMBL14631557 | 0.79 | HTR2A (0.50) | PDPK1MAPK8HTR2ATTKKEAP1 | |
| SCHEMBL16681561 | 0.78 | GAA (0.51) | GAAPDPK1ROCK1CDK5CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738962-B1 | SALTS OF A COMPOUND AND USE THEREOF | MEDSPRING INTERNATIONAL LTD (CN) | 2023-08-02 | — | — | EP | disclosed |
| EP-3738962-B1 | SALTS OF A COMPOUND AND USE THEREOF | MEDSPRING INTERNATIONAL LTD (CN) | 2023-08-02 | — | — | EP | disclosed |
| CN-110818683-B | 2-pyridine substituted urea structure small molecule compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2023-04-14 | — | — | CN | disclosed |
| CN-110028501-B | Compound and preparation method and application thereof | 迈德欣国际有限公司 | 2022-02-22 | — | — | CN | disclosed |
| EP-3515894-B1 | INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES | NOVARTIS AG (CH) | 2021-04-07 | — | — | EP | disclosed |
| US-20210078985-A1 | COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | MEDSPRING INTERNATIONAL LIMITED (CN) | 2021-03-18 | — | — | US | disclosed |
| US-20210078985-A1 | COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | MEDSPRING INTERNATIONAL LIMITED (CN) | 2021-03-18 | — | — | US | disclosed |
| EP-3738962-A1 | COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Medspring International Limited (CN) | 2020-11-18 | — | — | EP | disclosed |
| EP-3738962-A1 | COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | Medspring International Limited (CN) | 2020-11-18 | — | — | EP | disclosed |
| US-10668071-B2 | (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2020-06-02 | — | — | US | disclosed |
| US-20120015932-A1 | Pyrazole Derivatives Used as CCR4 Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2012-01-19 | — | — | US | disclosed |
| EP-2401270-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | Glaxo Group Limited (GB) | 2012-01-04 | — | — | EP | disclosed |
| WO-2011120025-A1 | INDAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2011-09-29 | — | — | WO | disclosed |
| EP-2227464-A1 | DERIVATIVES OF 1-[(IMIDAZOLIDIN-2-YL)IMINO)]INDAZOLE | Imperial Innovations Limited (GB) | 2010-09-15 | — | — | EP | disclosed |
| WO-2010097395-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-09-02 | — | — | WO | disclosed |
| WO-2010097395-A1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2010-09-02 | — | — | WO | disclosed |
| US-20100216860-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | US | disclosed |
| US-20100216860-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | US | disclosed |
| US-20100216860-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-08-26 | — | — | US | disclosed |
| WO-2009071906-A1 | DERIVATIVES OF 1-[(IMIDAZOLIDIN-2-YL)IMINO)]INDAZOLE | IMPERIAL INNOVATIONS LIMITED (GB) | 2009-06-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210078985-A1 | COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF | CCR4, CCR1, CCL11 | GAA 1217/4885PDPK1 3407/4885ROCK1 1568/4885 |
| US-10668071-B2 | (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use | SERPINB6, SERPINC1, SERPINE1 | GAA 3619/4885PDPK1 1304/4885ROCK1 1501/4885 |
| US-20120015932-A1 | Pyrazole Derivatives Used as CCR4 Receptor Antagonists | CCR4, CCR3, CCR1 | GAA 4288/4885PDPK1 610/4885ROCK1 3821/4885 |
| US-20100216860-A1 | NOVEL COMPOUNDS | CYP3A4, CYP3A43, ABCG2 | GAA 303/4885PDPK1 221/4885ROCK1 1329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.