Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18526322 | 0.92 | NT5E (0.41) | NT5ERORCTTRKCNH2JAK2 | |
| SCHEMBL29720341 | 0.91 | KCNH2 (0.34) | NT5ERORCKCNH2KLKB1MAPT | |
| SCHEMBL18526377 | 0.91 | KCNH2 (0.34) | NT5ERORCKCNH2KLKB1MAPT | |
| SCHEMBL24942508 | 0.89 | NT5E (0.40) | NT5ERORCTTRKCNH2JAK2 | |
| SCHEMBL30112567 | 0.89 | NT5E (0.40) | NT5ERORCTTRKCNH2JAK2 | |
| SCHEMBL31696933 | 0.88 | NT5E (0.37) | NT5ERORCTTRKCNH2JAK2 | |
| SCHEMBL23651247 | 0.88 | NT5E (0.39) | NT5ERORCTTRKCNH2JAK2 | |
| SCHEMBL31398727 | 0.88 | NT5E (0.39) | NT5ERORCTTRKCNH2JAK2 | |
| SCHEMBL24942980 | 0.87 | NT5E (0.39) | NT5ERORCTTRKCNH2JAK2 | |
| SCHEMBL30112650 | 0.87 | NT5E (0.39) | NT5ERORCTTRKCNH2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190107534-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | HOWARD HUGHES MEDICAL INSTITUTE | 2019-04-11 | — | — | US | disclosed |
| US-20180172677-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | HOWARD HUGHES MEDICAL INSTITUTE | 2018-06-21 | — | — | US | disclosed |
| US-9933417-B2 | Azetidine-substituted fluorescent compounds | HOWARD HUGHES MEDICAL INSTITUTE (US) | 2018-04-03 | — | — | US | disclosed |
| US-20170045501-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | HOWARD HUGHES MEDICAL INSTITUTE | 2017-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170045501-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | AANAT, HNMT, CHAT | NT5E 224/4885RORC 3122/4885TTR 2795/4885 |
| US-20180172677-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | AANAT, HNMT, CHAT | NT5E 224/4885RORC 3122/4885TTR 2795/4885 |
| US-20190107534-A1 | AZETIDINE-SUBSTITUTED FLUORESCENT COMPOUNDS | AANAT, HNMT, CHAT | NT5E 224/4885RORC 3122/4885TTR 2795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.