Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18520393 | 0.84 | ADK (0.49) | ADKLRRK2DYRK1AMAP4K4PRKACA | |
| SCHEMBL26831072 | 0.80 | RPS6KB1 (0.47) | ADKDYRK1ARPS6KB1DYRK3ROCK2 | |
| SCHEMBL7695926 | 0.78 | ADK (0.45) | ADKLRRK2DYRK1ACFDSRC | |
| SCHEMBL16236495 | 0.78 | DYRK3 (0.67) | ADKDYRK1ARPS6KB1DYRK3ROCK2 | |
| SCHEMBL6364076 | 0.78 | KDR (0.56) | ADKLRRK2DYRK1ASRCKDR | |
| SCHEMBL29052166 | 0.78 | ADORA2A (0.50) | ADKDYRK1ARPS6KB1DYRK3ROCK2 | |
| SCHEMBL29781064 | 0.78 | ADORA2A (0.50) | ADKDYRK1ARPS6KB1DYRK3ROCK2 | |
| SCHEMBL7698564 | 0.76 | ADK (0.43) | ADKLRRK2DYRK1ARPS6KB1ROCK2 | |
| SCHEMBL6434095 | 0.76 | LRRK2 (0.54) | ADKLRRK2DYRK1AMAP4K4PRKACA | |
| SCHEMBL7700385 | 0.76 | ADORA2A (0.52) | ADKLRRK2CFDSRCPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027645-A1 | CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-02-16 | — | — | WO | disclosed |