SCHEMBL18527386

SCHEMBL18527386

COc1ccc(-c2c(O)oc3cc(=O)ccc-3c2O)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 1/20 0.51
▸ HDAC4 P56524 1/20 0.44
▸ HDAC2 Q92769 1/20 0.44
▸ HDAC8 Q9BY41 1/20 0.44
▸ MEN1 O00255 6/20 0.44
▸ KMT2A Q03164 6/20 0.44
▸ MAOB P27338 3/20 0.44
▸ POLB P06746 2/20 0.42
▸ GAA P10253 1/20 0.42
▸ GRK6 P43250 1/20 0.42
▸ BLM P54132 1/20 0.42
▸ GFER P55789 1/20 0.42
▸ NPC1 O15118 4/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ ACLY P53396 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ PPARG P37231 1/20 0.41
▸ MAPT P10636 3/20 0.41
▸ TP53 P04637 2/20 0.41
▸ CYP3A4 P08684 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10167876 0.76 MEN1 (0.72) MEN1KMT2AMAOBPOLBNPC1
SCHEMBL21316776 0.74 NQO1 (0.56) MEN1KMT2AMAOBPOLBGAA
SCHEMBL11122148 0.70 HDAC4 (0.62) HDAC4HDAC2HDAC8MEN1KMT2A
SCHEMBL24425880 0.69 EGFR (1.00) EGFRMEN1KMT2AMAOBNPC1
SCHEMBL28068547 0.69 LCK (0.44) MEN1KMT2APOLBALDH1A1MAPK1
SCHEMBL9052961 0.67 CA1 (0.71) MEN1KMT2AMAOBNPC1ALDH1A1
SCHEMBL23459097 0.66 MAOA (0.56) MEN1KMT2AMAOBPOLBGAA
SCHEMBL3671202 0.66 HDAC4 (0.56) HDAC4HDAC2HDAC8MEN1KMT2A
SCHEMBL28104365 0.65 MAOB (0.64) MEN1KMT2AMAOBNPC1ALDH1A1
SCHEMBL16804613 0.64 KDM4E (0.56) MEN1KMT2AMAOBPOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3442497-B1 ACTIVE COMBINATIONS, COMPOSITIONS AND METHODS FOR ENHANCING HAIR GROWTH GRATIA MUNDI GMBH (DE) 2021-06-09 — — EP disclosed
EP-3442497-A1 ACTIVE COMBINATIONS, COMPOSITIONS AND METHODS FOR ENHANCING HAIR GROWTH Gratia Mundi GmbH (DE) 2019-02-20 — — EP disclosed
WO-2017032711-A1 ACTIVE COMBINATIONS, COMPOSITIONS AND METHODS FOR ENHANCING HAIR GROWTH GRATIA MUNDI GMBH (DE) 2017-03-02 — — WO disclosed
US-20170049689-A1 ACTIVE COMBINATIONS, COMPOSITIONS AND METHODS FOR ENHANCING HAIR GROWTH GRATIA MUNDI GMBH (DE) 2017-02-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170049689-A1 ACTIVE COMBINATIONS, COMPOSITIONS AND METHODS FOR ENHANCING HAIR GROWTH FGF1, EYA3, FGF2 EGFR 97/4885HDAC4 652/4885HDAC2 371/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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