Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATG4B | Q9Y4P1 | 17/20 | 0.64 |
| ▸ | CDK2 | P24941 | 2/20 | 0.64 |
| ▸ | GSK3A | P49840 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.64 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1394887 | 0.78 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL27575922 | 0.77 | CFD (0.54) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18529270 | 0.76 | SMN1; SMN2 (0.48) | ALDH1A1POLBCASP3SENP8SENP7 | |
| SCHEMBL30339380 | 0.76 | SMN1; SMN2 (0.58) | ALDH1A1POLBCASP3SENP8SENP7 | |
| SCHEMBL18541829 | 0.74 | ALDH1A1 (0.52) | GSK3BALDH1A1POLBL3MBTL1MEN1 | |
| SCHEMBL7449639 | 0.74 | CFD (0.47) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL15306500 | 0.73 | NAMPT (0.72) | ALDH1A1POLBMEN1MAPTKMT2A | |
| SCHEMBL7853963 | 0.72 | CXCR1 (0.67) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18541826 | 0.72 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL24074135 | 0.71 | GAA (0.62) | DYRK1AALDH1A1POLBMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027984-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CANCER BY INHIBITING ATG4B AND BLOCKING AUTOPHAGY | SIMON FRASER UNIVERSITY (CA) | 2017-02-23 | — | — | WO | disclosed |
| WO-2017027984-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CANCER BY INHIBITING ATG4B AND BLOCKING AUTOPHAGY | SIMON FRASER UNIVERSITY (CA) | 2017-02-23 | — | — | WO | disclosed |