Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATG4B | Q9Y4P1 | 18/20 | 1.00 |
| ▸ | CDK2 | P24941 | 1/20 | 0.78 |
| ▸ | GSK3A | P49840 | 1/20 | 0.78 |
| ▸ | GSK3B | P49841 | 1/20 | 0.78 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.78 |
| ▸ | HIPK4 | Q8NE63 | 1/20 | 0.78 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | RAB9A | P51151 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18529282 | 0.93 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL1394887 | 0.88 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18529266 | 0.83 | RAB9A (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18541826 | 0.81 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18529261 | 0.81 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18541905 | 0.81 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL13694246 | 0.80 | MEN1 (0.77) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18529262 | 0.80 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL376089 | 0.80 | MEN1 (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A | |
| SCHEMBL18529250 | 0.79 | ATG4B (1.00) | ATG4BCDK2GSK3AGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027984-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CANCER BY INHIBITING ATG4B AND BLOCKING AUTOPHAGY | SIMON FRASER UNIVERSITY (CA) | 2017-02-23 | — | — | WO | disclosed |
| WO-2017027984-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CANCER BY INHIBITING ATG4B AND BLOCKING AUTOPHAGY | SIMON FRASER UNIVERSITY (CA) | 2017-02-23 | — | — | WO | disclosed |