Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18541825 | 0.90 | ABL1 (0.54) | RIPK1ABL1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL27093079 | 0.84 | RIPK1 (0.72) | RIPK1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL14300399 | 0.83 | ABL1 (0.58) | MAPTABL1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL28240295 | 0.81 | RIPK1 (0.66) | RIPK1MAPTMEN1KMT2AABL1 | |
| SCHEMBL5743892 | 0.81 | RAB9A (0.74) | RIPK1MAPTMEN1KMT2ANPC1 | |
| SCHEMBL18541827 | 0.78 | GSK3B (0.59) | ABL1RAB9ASMN1; SMN2GSK3B | |
| SCHEMBL19329479 | 0.78 | RIPK1 (0.63) | RIPK1MAPTMEN1KMT2AABL1 | |
| SCHEMBL18529293 | 0.76 | MAPT (0.63) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL31388529 | 0.76 | RIPK1 (0.60) | RIPK1MEN1KMT2AABL1SMN1; SMN2 | |
| SCHEMBL31388528 | 0.76 | RIPK1 (0.60) | RIPK1MEN1KMT2AABL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017027984-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CANCER BY INHIBITING ATG4B AND BLOCKING AUTOPHAGY | SIMON FRASER UNIVERSITY (CA) | 2017-02-23 | — | — | WO | disclosed |
| WO-2017027984-A1 | COMPOUNDS AND METHODS FOR TREATMENT OF CANCER BY INHIBITING ATG4B AND BLOCKING AUTOPHAGY | SIMON FRASER UNIVERSITY (CA) | 2017-02-23 | — | — | WO | disclosed |