Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.68 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | YAP1 | P46937 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18529974 | 1.00 | PADI1 (0.68) | PADI1PADI4KDM4EMAPTMEN1 | |
| SCHEMBL18530003 | 0.90 | PADI1 (0.54) | PADI1PADI4KDM4EMAPTMEN1 | |
| SCHEMBL18530001 | 0.90 | PADI1 (0.54) | PADI1PADI4KDM4EMAPTMEN1 | |
| SCHEMBL18529995 | 0.87 | PADI1 (0.74) | PADI1PADI4KDM4EMAPTKMT2A | |
| SCHEMBL18529963 | 0.86 | PADI1 (0.51) | PADI1PADI4MAPTMEN1KMT2A | |
| SCHEMBL20485587 | 0.86 | PADI1 (0.51) | PADI1PADI4MAPTMEN1KMT2A | |
| SCHEMBL18546459 | 0.82 | PADI1 (0.98) | PADI1PADI4MAPTKMT2AALOX15 | |
| SCHEMBL18546553 | 0.82 | PADI1 (0.98) | PADI1PADI4MAPTKMT2AALOX15 | |
| SCHEMBL18546885 | 0.79 | CTSL (0.46) | KDM4EMEN1KMT2AACKR3 | |
| SCHEMBL18529998 | 0.79 | CTSL (0.46) | KDM4EMEN1KMT2AACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4198029-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | University Health Network (CA) | 2023-06-21 | — | — | EP | disclosed |
| EP-4198029-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | University Health Network (CA) | 2023-06-21 | — | — | EP | disclosed |
| EP-3337791-B1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIV HEALTH NETWORK (CA) | 2022-08-03 | — | — | EP | disclosed |
| US-10716791-B2 | Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof | UNIVERSITY HEALTH NETWORK (CA) | 2020-07-21 | — | — | US | disclosed |
| US-10716791-B2 | Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof | UNIVERSITY HEALTH NETWORK (CA) | 2020-07-21 | — | — | US | disclosed |
| US-20180250307-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2018-09-06 | — | — | US | disclosed |
| EP-3337791-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | University Health Network (CA) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017027967-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2017-02-23 | — | — | WO | disclosed |
| WO-2017027967-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10716791-B2 | Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof | PADI2, PADI1, PADI4 | PADI1 2/4885PADI4 3/4885KDM4E 2273/4885 |
| US-20180250307-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | PADI2, PADI1, PADI4 | PADI1 2/4885PADI4 3/4885KDM4E 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.