Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.41 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20485647 | 1.00 | PSMB5 (0.44) | PSMB5SMN1; SMN2GAAALOX15PADI1 | |
| SCHEMBL20485911 | 0.79 | SMN1; SMN2 (0.44) | PSMB5SMN1; SMN2GAAALOX15PADI1 | |
| SCHEMBL18529983 | 0.79 | SMN1; SMN2 (0.44) | PSMB5SMN1; SMN2GAAALOX15PADI1 | |
| SCHEMBL18935499 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAMAPK1TSHRMEN1 | |
| SCHEMBL104815 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAMAPK1TSHRMEN1 | |
| SCHEMBL24997802 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAMAPK1TSHRMEN1 | |
| SCHEMBL24997854 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAMAPK1TSHRMEN1 | |
| SCHEMBL18935418 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2GAAMAPK1TSHRMEN1 | |
| SCHEMBL20485577 | 0.76 | SMN1; SMN2 (0.38) | PSMB5SMN1; SMN2GAAALOX15PADI1 | |
| SCHEMBL18530000 | 0.76 | SMN1; SMN2 (0.38) | PSMB5SMN1; SMN2GAAALOX15PADI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4198029-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | University Health Network (CA) | 2023-06-21 | — | — | EP | disclosed |
| EP-3337791-B1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIV HEALTH NETWORK (CA) | 2022-08-03 | — | — | EP | disclosed |
| US-10716791-B2 | Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof | UNIVERSITY HEALTH NETWORK (CA) | 2020-07-21 | — | — | US | disclosed |
| US-20180250307-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2018-09-06 | — | — | US | disclosed |
| EP-3337791-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | University Health Network (CA) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017027967-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10716791-B2 | Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof | PADI2, PADI1, PADI4 | PSMB5 1847/4885SMN1; SMN2 4380/4885GAA 375/4885 |
| US-20180250307-A1 | INHIBITORS OF PEPTIDYL ARGININE DEIMINASE (PAD) ENZYMES AND USES THEREOF | PADI2, PADI1, PADI4 | PSMB5 1847/4885SMN1; SMN2 4380/4885GAA 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.