Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CCR1 | P32246 | 4/20 | 0.46 |
| ▸ | CCR8 | P51685 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 6/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.42 |
| ▸ | METAP1 | P53582 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | METAP2 | P50579 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18530814 | 0.81 | HSP90AA1 (0.47) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL18260476 | 0.77 | L3MBTL1 (0.46) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL21297755 | 0.77 | HSP90AA1 (0.73) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL12747793 | 0.77 | HSP90AA1 (0.53) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL14212958 | 0.73 | KDM4E (0.62) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL30454561 | 0.73 | HSP90AA1 (0.50) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL15624642 | 0.73 | L3MBTL1 (0.82) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL250356 | 0.72 | L3MBTL1 (1.00) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL22250697 | 0.72 | HSP90AA1 (0.59) | HSP90AA1L3MBTL1NPC1CCR1CCR8 | |
| SCHEMBL7435562 | 0.72 | PRMT5 (0.46) | HSP90AA1L3MBTL1NPC1CCR1CCR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200101068-A1 | Heteroaryl Derivatives as PARP Inhibitors | LUPIN LIMITED (IN) | 2020-04-02 | — | — | US | disclosed |
| US-20200101068-A1 | Heteroaryl Derivatives as PARP Inhibitors | LUPIN LIMITED (IN) | 2020-04-02 | — | — | US | disclosed |
| EP-3337802-A1 | HETEROARYL DERIVATIVES AS PARP INHIBITORS | Lupin Limited (IN) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017029601-A1 | HETEROARYL DERIVATIVES AS PARP INHIBITORS | LUPIN LIMITED (IN) | 2017-02-23 | — | — | WO | disclosed |
| WO-2017029601-A1 | HETEROARYL DERIVATIVES AS PARP INHIBITORS | LUPIN LIMITED (IN) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200101068-A1 | Heteroaryl Derivatives as PARP Inhibitors | PARP1, PARP2, PARP3 | HSP90AA1 3646/4885L3MBTL1 1695/4885NPC1 3385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.