Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 5/20 | 0.39 |
| ▸ | CCR8 | P51685 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CCR5 | P51681 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24953761 | 0.76 | PRMT5 (0.47) | PRMT5L3MBTL1HSP90AA1NPC1TDP1 | |
| SCHEMBL12564559 | 0.75 | PABPC1 (0.44) | PRMT5TDP1LMNAKDM4EMAPT | |
| SCHEMBL29958311 | 0.74 | KCNMA1 (0.41) | PRMT5L3MBTL1HSP90AA1TDP1CCR1 | |
| SCHEMBL28890484 | 0.74 | KCNMA1 (0.41) | PRMT5L3MBTL1HSP90AA1TDP1CCR1 | |
| SCHEMBL29108495 | 0.73 | LMNA (0.46) | PRMT5L3MBTL1TDP1LMNAKDM4E | |
| SCHEMBL30640157 | 0.73 | LMNA (0.46) | PRMT5L3MBTL1TDP1LMNAKDM4E | |
| SCHEMBL1991038 | 0.72 | KDM4E (0.43) | L3MBTL1NPC1LMNAKDM4EMAPT | |
| SCHEMBL18530804 | 0.72 | HSP90AA1 (0.55) | L3MBTL1HSP90AA1NPC1TDP1CCR1 | |
| SCHEMBL16541493 | 0.72 | PRMT5 (0.47) | PRMT5L3MBTL1HSP90AA1NPC1TDP1 | |
| SCHEMBL27109645 | 0.71 | PRMT5 (0.50) | PRMT5L3MBTL1HSP90AA1NPC1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410526-B1 | BONE DISORDERS; RESTENOSIS; VISION DISORDERS; ANTICHOLESTEROL AGENTS; ANTICANCER, ANTITUMOR AGENTS | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |