Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 0.65 |
| ▸ | ALK | Q9UM73 | 13/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501063 | 0.85 | PDPK1 (0.69) | PDPK1ALKTGFBR1IKBKETBK1 | |
| SCHEMBL12501027 | 0.80 | PDPK1 (0.62) | PDPK1ALKTGFBR1IKBKETNIK | |
| SCHEMBL12501057 | 0.79 | PDPK1 (1.00) | PDPK1ALKTGFBR1IKBKETBK1 | |
| SCHEMBL18098840 | 0.77 | PDPK1 (0.66) | PDPK1ALKTGFBR1IKBKETBK1 | |
| SCHEMBL12501148 | 0.77 | PDPK1 (0.61) | PDPK1ALKIKBKETBK1TNIK | |
| SCHEMBL26175331 | 0.71 | PDPK1 (0.52) | PDPK1ALK | |
| SCHEMBL21592663 | 0.71 | DYRK1A (0.66) | PDPK1ALK | |
| SCHEMBL15397145 | 0.70 | PDPK1 (0.84) | PDPK1ALKTNIK | |
| SCHEMBL18098833 | 0.70 | PDPK1 (0.61) | PDPK1TGFBR1IKBKETBK1TNIK | |
| SCHEMBL26175364 | 0.70 | ALK (0.59) | PDPK1ALKTNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |