Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 0.84 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.55 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501057 | 0.91 | PDPK1 (1.00) | PDPK1ALKTNIK | |
| SCHEMBL17738792 | 0.86 | PDPK1 (0.63) | PDPK1HTR6 | |
| SCHEMBL17742865 | 0.78 | PDPK1 (0.77) | PDPK1ALKHTR6 | |
| SCHEMBL2753672 | 0.76 | ALK (0.74) | PDPK1ALKTNIK | |
| SCHEMBL12501063 | 0.73 | PDPK1 (0.69) | PDPK1ALKTNIK | |
| SCHEMBL2750994 | 0.73 | PDPK1 (0.54) | PDPK1ALKHTR6 | |
| SCHEMBL3506020 | 0.73 | PDPK1 (0.54) | PDPK1ALKHTR6 | |
| SCHEMBL16698105 | 0.73 | PDPK1 (0.54) | PDPK1HTR6 | |
| SCHEMBL14365336 | 0.72 | HTR6 (0.58) | PDPK1HTR6 | |
| SCHEMBL12501042 | 0.72 | PDPK1 (0.68) | PDPK1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9725446-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2017-08-08 | — | — | US | disclosed |
| US-20150152104-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-06-04 | — | — | US | disclosed |
| US-8981101-B2 | 7-azaindole derivatives | MERCK PATENT GMBH (DE) | 2015-03-17 | — | — | US | disclosed |
| US-20130310391-A1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310391-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | PDPK1 12/4885ALK 2884/4885TNIK 1533/4885 |
| US-20150152104-A1 | 7-AZAINDOLE DERIVATIVES | PDK1, PDK2, PDK3 | PDPK1 12/4885ALK 2884/4885TNIK 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.