Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 9/20 | 0.66 |
| ▸ | ALK | Q9UM73 | 11/20 | 0.51 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501063 | 0.82 | PDPK1 (0.69) | PDPK1ALKTGFBR1IKBKETBK1 | |
| SCHEMBL22755778 | 0.81 | TGFBR1 (0.61) | PDPK1TGFBR1IKBKETBK1 | |
| SCHEMBL12501057 | 0.79 | PDPK1 (1.00) | PDPK1ALKTGFBR1IKBKETBK1 | |
| SCHEMBL12501027 | 0.77 | PDPK1 (0.62) | PDPK1ALKTGFBR1IKBKE | |
| SCHEMBL18534314 | 0.77 | PDPK1 (0.65) | PDPK1ALKTGFBR1IKBKETBK1 | |
| SCHEMBL12501148 | 0.76 | PDPK1 (0.61) | PDPK1ALKIKBKETBK1 | |
| SCHEMBL2753672 | 0.74 | ALK (0.74) | PDPK1ALK | |
| SCHEMBL15397145 | 0.71 | PDPK1 (0.84) | PDPK1ALK | |
| SCHEMBL18098820 | 0.70 | PDPK1 (0.48) | PDPK1TGFBR1IKBKETBK1 | |
| SCHEMBL26175331 | 0.69 | PDPK1 (0.52) | PDPK1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3133074-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-12-09 | — | — | EP | disclosed |
| EP-3133074-A2 | 7-AZAINDOLE DERIVATIVES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |
| EP-2670748-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |