Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | GLA | P06280 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18535528 | 0.85 | KDM4E (0.48) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18535532 | 0.81 | NPC1 (0.38) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18535503 | 0.80 | NPC1 (0.53) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18583689 | 0.79 | NPC1 (0.44) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL21116509 | 0.78 | RXFP1 (0.38) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18583380 | 0.78 | RAB9A (0.47) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18535561 | 0.77 | KDM4E (0.46) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18535420 | 0.77 | THRB (0.52) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18583371 | 0.76 | KDM4E (0.46) | NPC1RAB9AKDM4EGLAALDH1A1 | |
| SCHEMBL18535566 | 0.75 | RAB9A (0.45) | NPC1RAB9AKDM4EGLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017032442-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | MERCK PATENT GMBH (DE) | 2017-03-02 | — | — | WO | disclosed |
| EP-3133065-A1 | COMPOUNDS FOR OPTICALLY ACTIVE DEVICES | Merck Patent GmbH (DE) | 2017-02-22 | — | — | EP | disclosed |