Enoxolone

Enoxolone

SCHEMBL18539

CC1(C)C2CC[C@]3(C)[C@H](C(=O)C=C4[C@H]5C[C@@](C)(C(=O)O)CC[C@]5(C)CC[C@]43C)[C@@]2(C)CC[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 10/20 1.00
HSD11B2 P80365 9/20 1.00
CES2 O00748 5/20 1.00
CES1 P23141 5/20 1.00
PTPN1 P18031 3/20 1.00
CYP3A4 P08684 2/20 1.00
MAPT P10636 2/20 1.00
ALOX5 P09917 2/20 1.00
MEN1 O00255 1/20 1.00
AKR1B10 O60218 1/20 1.00
LMNA P02545 1/20 1.00
PRKCH P24723 1/20 1.00
PTPN6 P29350 1/20 1.00
KMT2A Q03164 1/20 1.00
PTPN11 Q06124 1/20 1.00
SLCO1B3 Q9NPD5 1/20 1.00
SLCO1B1 Q9Y6L6 1/20 1.00
TSHR P16473 1/20 1.00
HSD17B1 P14061 1/20 0.76
HSD17B2 P37059 1/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Enoxolone SCHEMBL1878063 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL8896296 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL19248152 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL13144257 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL23016683 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL2762928 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL23252837 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL12444056 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL14071726 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1
Enoxolone SCHEMBL12225660 1.00 HSD11B1 (1.00) HSD11B1HSD11B2CES2CES1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 17449 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122075400-A Anti-inflammatory small molecule-loaded exosome temperature-sensitive hydrogel and preparation method and application thereof 2026-05-26 CN claimed
CN-116270428-B Glycyrrhetinic acid injectable hydrogel and preparation method and application thereof 广西医科大学 2026-05-19 CN claimed
CN-122060015-A Pt (IV) -glycyrrhetinic acid compound and preparation method and application thereof 重庆大学 2026-05-19 CN claimed
CN-119709534-B Lactobacillus paracasei capable of transforming liquorice to strengthen liquorice and relieving lipid accumulation, oxidative damage and inflammatory reaction 江南大学 2026-05-19 CN claimed
CN-122056786-A Lipid hybridization nanoparticle and preparation method and application thereof 上海世领制药有限公司 2026-05-19 CN claimed
CN-122031295-A Application of small molecule natural active leech extraction in cosmetic technology 广西蜞珍生物科技有限公司 2026-05-15 CN claimed
CN-122031397-A Method for improving solubility and stability of betulinol 甘肃农业大学 2026-05-15 CN claimed
CN-122011079-A Glycyrrhetinic acid-tromethamine eutectic crystal and preparation method and application thereof in skin care 临沂大学 2026-05-12 CN claimed
CN-122005383-A Oily skin care composition and preparation method and application thereof 北京东方淼森生物科技有限公司 2026-05-12 CN claimed
CN-122012662-A Process for green synthesis of high-purity stearyl glycyrrhetinate based on enzyme catalysis 甘肃泛植制药有限公司 2026-05-12 CN claimed
EP-0087993-B1 PULVERIZED MIXTURE OF LIPID AND HYDROPHOBIC CONSTITUENTS, PROCESS FOR PREPARING THEM, HYDRATED LIPID LAMELLAR PHASES AND PROCESS FOR PREPARING THEM, PHARMACEUTICAL OR COSMETIC COMPOSITIONS CONTAINING HYDRATED LAMELLAR LIPID PHASES PARFUMS CHRISTIAN DIOR (FR) 1986-07-02 EP claimed
US-4548950-A GLYCYRRHETINIC ACID DERIVATIVE AND SALT AS STABILIZER BIOREX LABORATORIES LIMITED (GB) 1985-10-22 US claimed
US-4545990-A BENZOYL PEROXIDE AND COLLAGENIC PALMITOYL ACID, GLYCYRRHETINIC ACID, OR BISABOLOL, MERISTEM EXTRACT L'OREAL (FR) 1985-10-08 US claimed
EP-0156565-A2 Antipruritic compositions and plasters YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1985-10-02 EP claimed
US-4540567-A ALKYL LACTATE, ALKYLENE GLYCOL, ACNE TREATMENT LEVER BROTHERS COMPANY (US) 1985-09-10 US claimed
US-4508703-A DISSOLVING IN NONAQUEOUS SOLVENT, ATOMIZING PARFUMS CHRISTIAN DIOR (FR) 1985-04-02 US claimed
US-4406882-A GLYCYRRHETINIC ACID, ESTER DERIVATIVES BIOREX LABORATORIES LIMITED (GB) 1983-09-27 US claimed
US-4374284-A Antiulcer, antiinflammatory, and antiallergic agent comprising as the main ingredient olean-12-ene-3β, 30-diol which is devoid of side effects of glycyrrhetinic acid and a new process for preparation of olean-12-ene-3β, 30-diol MINOPHAGEN PHARMACEUTICAL COMPANY (JP) 1983-02-15 US claimed
US-4246040-A REACTING BASIC POLYALUMINUM SALT WITH AN ACID IN PRESENCE OF POWDER NIHONSHIKIZAI KOGYO CO., LTD. (JP) 1981-01-20 US claimed
US-3953423-A Preparation of a new flavanone derivative H. TROMMSDORFF (DT) 1976-04-27 US claimed