Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 8/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.63 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.63 |
| ▸ | SAE1 | Q9UBE0 | 2/20 | 0.63 |
| ▸ | UBA2 | Q9UBT2 | 2/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 6/20 | 0.61 |
| ▸ | PTPN12 | Q05209 | 4/20 | 0.61 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.61 |
| ▸ | PTPN22 | Q9Y2R2 | 4/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.59 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.57 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | NSD2 | O96028 | 1/20 | 0.56 |
| ▸ | ALPL | P05186 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31377033 | 0.95 | NPC1 (0.72) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL31376976 | 0.94 | NPC1 (0.71) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL12008589 | 0.91 | MEN1 (0.76) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL18539160 | 0.90 | NPC1 (0.84) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL31377003 | 0.88 | GPR35 (0.64) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL31376962 | 0.86 | GPR35 (0.66) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL31376994 | 0.86 | NPC1 (0.65) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL31376947 | 0.85 | GPR35 (0.63) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL31376972 | 0.85 | GPR35 (0.63) | NPC1MEN1KMT2ATDP1PSMD14 | |
| SCHEMBL31377011 | 0.85 | GPR35 (0.65) | NPC1MEN1KMT2ATDP1PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | DASGUPTA RAMANUJ (US) | 2017-02-23 | — | — | US | disclosed |
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | DASGUPTA RAMANUJ (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | CTNNB1, CTNNA1, CTNNBL1 | NPC1 1604/4885MEN1 4655/4885KMT2A 4591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.