Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.84 |
| ▸ | PTPN12 | Q05209 | 4/20 | 0.74 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.74 |
| ▸ | PTPN22 | Q9Y2R2 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 10/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.65 |
| ▸ | POLB | P06746 | 7/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | NSD2 | O96028 | 1/20 | 0.63 |
| ▸ | ALPL | P05186 | 1/20 | 0.63 |
| ▸ | ALPI | P09923 | 1/20 | 0.63 |
| ▸ | ALPG | P10696 | 1/20 | 0.63 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.63 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.63 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12008726 | 0.90 | PTPN12 (0.90) | NPC1PTPN12GPR35PTPN22MEN1 | |
| SCHEMBL18539156 | 0.90 | NPC1 (0.80) | NPC1PTPN12GPR35PTPN22MEN1 | |
| SCHEMBL12008709 | 0.85 | PTPN12 (1.00) | PTPN12GPR35PTPN22MEN1KMT2A | |
| SCHEMBL31377033 | 0.85 | NPC1 (0.72) | NPC1PTPN12GPR35PTPN22MEN1 | |
| SCHEMBL31376976 | 0.84 | NPC1 (0.71) | NPC1PTPN12GPR35PTPN22MEN1 | |
| SCHEMBL12008722 | 0.83 | PTPN12 (0.77) | PTPN12GPR35PTPN22MEN1KMT2A | |
| SCHEMBL12008606 | 0.82 | PTPN12 (0.76) | NPC1PTPN12GPR35PTPN22MEN1 | |
| SCHEMBL12008716 | 0.82 | NPC1 (0.83) | NPC1PTPN12GPR35PTPN22MEN1 | |
| SCHEMBL12008563 | 0.82 | GPR35 (0.76) | NPC1PTPN12GPR35PTPN22MEN1 | |
| SCHEMBL12008589 | 0.81 | MEN1 (0.76) | NPC1PTPN12GPR35PTPN22MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | DASGUPTA RAMANUJ (US) | 2017-02-23 | — | — | US | disclosed |
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | DASGUPTA RAMANUJ (US) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170049751-A1 | OXAZOLE AND THIAZOLE COMPOUNDS AS BETA-CATENIN MODULATORS AND USES THEREOF | CTNNB1, CTNNA1, CTNNBL1 | NPC1 1604/4885PTPN12 457/4885GPR35 299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.