Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL18528205 | 0.99 | KDM4E (0.47) | KDM4EAURKAALDH1A1WNT3ATNKS2 | |
| SCHEMBL18528169 | 0.88 | ALDH1A1 (0.46) | KDM4EALDH1A1AKT1MEN1KMT2A | |
| SCHEMBL18528154 | 0.87 | KDM4E (0.40) | KDM4EALDH1A1KMT2AGAAHPGD | |
| SCHEMBL20365653 | 0.84 | ALDH1A1 (0.43) | KDM4EALDH1A1WNT3ATNKS2AKT1 | |
| SCHEMBL18539535 | 0.83 | ALDH1A1 (0.41) | KDM4EALDH1A1WNT3ATNKS2AKT1 | |
| SCHEMBL18539533 | 0.83 | ALDH1A1 (0.39) | KDM4EALDH1A1WNT3ATNKS2AKT1 | |
| SCHEMBL18539527 | 0.82 | TYK2 (0.40) | ALDH1A1WNT3ATNKS2AKT1MEN1 | |
| SCHEMBL18548388 | 0.81 | KIF18A (0.35) | KDM4EAURKAALDH1A1KMT2ARAB9A | |
| SCHEMBL18539529 | 0.79 | AKT1 (0.42) | KDM4EALDH1A1WNT3ATNKS2AKT1 | |
| SCHEMBL20365665 | 0.79 | AKT1 (0.42) | KDM4EALDH1A1WNT3ATNKS2AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9670219-B2 | Tetrahydrooxepinopyridine compound | ASTELLAS PHARMA INC. (JP) | 2017-06-06 | — | — | US | disclosed |
| US-9670219-B2 | Tetrahydrooxepinopyridine compound | ASTELLAS PHARMA INC. (JP) | 2017-06-06 | — | — | US | disclosed |
| US-20170050973-A1 | TETRAHYDROOXEPINOPYRIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2017-02-23 | — | — | US | disclosed |
| US-20170050973-A1 | TETRAHYDROOXEPINOPYRIDINE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2017-02-23 | — | — | US | disclosed |
| WO-2017030171-A1 | TETRAHYDROOXEPINOPYRIDINE COMPOUND | アステラス製薬株式会社 | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050973-A1 | TETRAHYDROOXEPINOPYRIDINE COMPOUND | CHRNA7, CHRNA5, P2RX7 | KDM4E 2924/4885AURKA 3801/4885ALDH1A1 3958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.