Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 1/20 | 0.57 |
| ▸ | CTSL | P07711 | 3/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18540679 | 0.90 | C1S (0.55) | C1SCTSLPARP1MAPTMEN1 | |
| SCHEMBL30136033 | 0.80 | FASN (0.61) | CTSLPARP1KDM4EEGLN2CA12 | |
| SCHEMBL4511367 | 0.80 | PARP1 (0.57) | C1SCTSLPARP1KDM4EEGLN2 | |
| SCHEMBL18529814 | 0.80 | FASN (0.61) | CTSLPARP1KDM4EEGLN2CA12 | |
| SCHEMBL29505543 | 0.78 | — | — | |
| SCHEMBL49927 | 0.78 | — | — | |
| SCHEMBL931503 | 0.77 | C1S (0.53) | C1SCTSLPARP1MEN1KMT2A | |
| SCHEMBL932511 | 0.77 | C1S (0.53) | C1SCTSLPARP1MAPTMEN1 | |
| SCHEMBL31174803 | 0.76 | CTSL (0.61) | C1SCTSLPARP1KDM4EEGLN2 | |
| Phosphine SCHEMBL4337915 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017030983-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF CATHEPSINS | MATEON THERAPEUTICS, INC. (US) | 2017-02-23 | — | — | WO | disclosed |