Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 4/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15372989 | 0.78 | C1S (0.47) | C1SCTSLPARP1MEN1KMT2A | |
| SCHEMBL932511 | 0.78 | C1S (0.53) | C1SCTSLPARP1MEN1KMT2A | |
| SCHEMBL9125529 | 0.78 | CES2 (0.59) | C1SCTSLHSD11B1PARP1MEN1 | |
| SCHEMBL2282074 | 0.78 | CTSL (0.49) | C1SCTSLHSD11B1PARP1MEN1 | |
| SCHEMBL1635669 | 0.78 | PARP1 (0.53) | CTSLHSD11B1PARP1MEN1KMT2A | |
| SCHEMBL931923 | 0.77 | C1S (0.49) | C1SPARP1MEN1KMT2AALDH1A1 | |
| SCHEMBL8277840 | 0.77 | C1S (0.45) | C1SPARP1MEN1KMT2ACYP1A2 | |
| SCHEMBL932545 | 0.77 | C1S (0.45) | C1SPARP1MEN1KMT2AATM | |
| SCHEMBL18540697 | 0.77 | C1S (0.57) | C1SCTSLPARP1MEN1KMT2A | |
| SCHEMBL4476448 | 0.77 | CES2 (0.52) | MAOBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |