Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.45 |
| ▸ | TUBB | P07437 | 1/20 | 0.45 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.45 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.45 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.45 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.45 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.45 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.45 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.45 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.45 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.45 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.45 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.45 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17528551 | 0.83 | PDGFRB (0.56) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL19009085 | 0.83 | EGFR (0.43) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL18540825 | 0.78 | PDGFRB (0.51) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL21340792 | 0.78 | PDGFRB (0.51) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL30204235 | 0.78 | EGFR (0.64) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL24971011 | 0.78 | EGFR (0.64) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL18540839 | 0.77 | PDGFRB (0.50) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL14974588 | 0.76 | TUBB3 (0.51) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL18552631 | 0.75 | PDGFRB (0.48) | PDGFRBEGFRKDRTUBB3TUBB4A | |
| SCHEMBL11662793 | 0.74 | CA2 (0.48) | ALDH1A1HPGDHSD17B10CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210246141-A1 | Pyrazolo[4,3-d]pyrimidines as Antitumor Agents | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2021-08-12 | — | — | US | disclosed |
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-08-03 | — | — | US | disclosed |
| US-11001595-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2021-05-11 | — | — | US | disclosed |
| US-10858361-B2 | Pyrazolo[4,3-d]pyrimidines as antitumor agents | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-12-08 | — | — | US | disclosed |
| US-20200369680-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-11-26 | — | — | US | disclosed |
| US-20200255431-A1 | Pyrazolo[4,3-d]pyrimidines as Antitumor Agents | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2020-08-13 | — | — | US | disclosed |
| US-10689386-B2 | Pyrazolo[4,3-d]pyrimidines as antitumor agents | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190276457-A1 | Pyrazolo[4,3-d]pyrimidines as Antitumor Agents | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2019-09-12 | — | — | US | disclosed |
| US-9994586-B2 | Monocyclic, thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-12 | — | — | US | disclosed |
| US-9994586-B2 | Monocyclic, thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of the same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-06-12 | — | — | US | disclosed |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2017-02-23 | — | — | US | disclosed |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200369680-A1 | PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE | DPYD, HPRT1, TPMT | PDGFRB 997/4885EGFR 1764/4885KDR 3566/4885 |
| US-10858361-B2 | Pyrazolo[4,3-d]pyrimidines as antitumor agents | RB1, RRM2, RRM2B | PDGFRB 965/4885EGFR 2005/4885KDR 352/4885 |
| US-20210246141-A1 | Pyrazolo[4,3-d]pyrimidines as Antitumor Agents | RB1, RRM2, RRM2B | PDGFRB 965/4885EGFR 2005/4885KDR 352/4885 |
| US-20190276457-A1 | Pyrazolo[4,3-d]pyrimidines as Antitumor Agents | DPYD, TP53, TYMP | PDGFRB 1479/4885EGFR 1235/4885KDR 1862/4885 |
| US-10689386-B2 | Pyrazolo[4,3-d]pyrimidines as antitumor agents | DPYD, TP53, TYMP | PDGFRB 1479/4885EGFR 1235/4885KDR 1862/4885 |
| US-20200255431-A1 | Pyrazolo[4,3-d]pyrimidines as Antitumor Agents | RB1, RRM2, RRM2B | PDGFRB 965/4885EGFR 2005/4885KDR 352/4885 |
| US-11078214-B2 | Monocyclic thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of same | DPYD, TYMS, THPO | PDGFRB 1782/4885EGFR 2600/4885KDR 2597/4885 |
| US-20170050978-A1 | Monocyclic, Thieno, Pyrido, and Pyrrolo Pyrimidine Compounds and Methods of Use and Manufacture of the Same | CYP4F3, TYMS, DPYD | PDGFRB 1108/4885EGFR 1667/4885KDR 1696/4885 |
| US-11001595-B2 | Pyrimidine compounds and pyrimido indole compounds and methods of use | DPYD, HPRT1, TPMT | PDGFRB 997/4885EGFR 1764/4885KDR 3566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.