Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CX3CR1 | P49238 | 20/20 | 0.61 |
| ▸ | CXCR2 | P25025 | 18/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1856003 | 0.90 | CX3CR1 (0.55) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL1852446 | 0.90 | CX3CR1 (0.65) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL23828014 | 0.88 | CX3CR1 (0.78) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL1854837 | 0.88 | CX3CR1 (0.78) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL23828016 | 0.88 | CX3CR1 (0.78) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL31199199 | 0.88 | CX3CR1 (0.78) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL213496 | 0.82 | CX3CR1 (0.76) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL213969 | 0.82 | CX3CR1 (0.76) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL213475 | 0.82 | CX3CR1 (0.76) | CX3CR1CXCR2ADORA1 | |
| SCHEMBL1854158 | 0.81 | CX3CR1 (0.61) | CX3CR1CXCR2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069364-B1 | NOVEL 5, 7-DISUBSTITUTED [1, 3]THIAZOLO [4, 5-D]PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2011-12-14 | — | — | EP | disclosed |
| EP-2069364-B1 | NOVEL 5, 7-DISUBSTITUTED [1, 3]THIAZOLO [4, 5-D]PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2011-12-14 | — | — | EP | disclosed |
| US-7960395-B2 | 5,7-disubstituted thiazolo[4,5-d]pyrimidines for the selective inhibition of chemokine receptors | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |
| US-7960395-B2 | 5,7-disubstituted thiazolo[4,5-d]pyrimidines for the selective inhibition of chemokine receptors | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |
| US-7960395-B2 | 5,7-disubstituted thiazolo[4,5-d]pyrimidines for the selective inhibition of chemokine receptors | ASTRAZENECA AB (SE) | 2011-06-14 | — | — | US | disclosed |
| US-20110105537-A1 | 5,7-DISUBSTITUTED THIAZOLO[4,5-D]PYRIMIDINES FOR THE SELECTIVE INHIBITION OF CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105537-A1 | 5,7-DISUBSTITUTED THIAZOLO[4,5-D]PYRIMIDINES FOR THE SELECTIVE INHIBITION OF CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | US | disclosed |
| US-20110105537-A1 | 5,7-DISUBSTITUTED THIAZOLO[4,5-D]PYRIMIDINES FOR THE SELECTIVE INHIBITION OF CHEMOKINE RECEPTORS | ASTRAZENECA AB (SE) | 2011-05-05 | — | — | US | disclosed |
| US-20080318981-A1 | Novel Compounds 480 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318981-A1 | Novel Compounds 480 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318981-A1 | Novel Compounds 480 | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| WO-2008039138-A1 | NOVEL 5, 7-DISUBSTITUTED [1, 3 ] THIAZOLO [4, 5-D] PYRIMIDIN-2 (3H)-ONE DERIVATIVES AND THEIR USE IN THERAPY | ASTRAZENECA AB (SE) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318981-A1 | Novel Compounds 480 | CX3CR1, CCR2, CXCR3 | CX3CR1 1/4885CXCR2 6/4885ADORA1 188/4885 |
| US-20110105537-A1 | 5,7-DISUBSTITUTED THIAZOLO[4,5-D]PYRIMIDINES FOR THE SELECTIVE INHIBITION OF CHEMOKINE RECEPTORS | CX3CR1, CCR2, CXCR3 | CX3CR1 1/4885CXCR2 5/4885ADORA1 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.