Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.79 |
| ▸ | TP53 | P04637 | 6/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | GAA | P10253 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | F2 | P00734 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25349392 | 0.95 | TP53 (0.88) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL25347981 | 0.89 | TP53 (0.88) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL18546039 | 0.89 | TP53 (0.69) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL18545998 | 0.88 | HSP90AA1 (0.70) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL834715 | 0.87 | TP53 (1.00) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL18545996 | 0.85 | HSP90AA1 (0.66) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL18546049 | 0.84 | ALDH1A1 (0.63) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL18545992 | 0.82 | ALDH1A1 (0.61) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL22722163 | 0.82 | ALDH1A1 (0.69) | HSP90AA1TP53LMNAALDH1A1KMT2A | |
| SCHEMBL25349325 | 0.81 | TP53 (0.75) | HSP90AA1TP53LMNAALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851051-B2 | Compositions and methods for treating multiple myeloma | THE BROAD INSTITUTE, INC. (US) | 2020-12-01 | — | — | US | disclosed |
| WO-2017030987-A9 | COMPOSITIONS AND METHODS FOR TREATING MULTIPLE MYELOMA | THE BROAD INSTITUTE, INC. (US) | 2018-07-12 | — | — | WO | disclosed |
| WO-2017030987-A1 | COMPOSITIONS AND METHODS FOR TREATING MULTIPLE MYELOMA | THE BROAD INSTITUTE, INC. (US) | 2017-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851051-B2 | Compositions and methods for treating multiple myeloma | BRIX1, UBQLN1, PRTN3 | HSP90AA1 2894/4885TP53 406/4885LMNA 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.