Sugi Predict

Sugi Predict / Compounds / SCHEMBL18548607

SCHEMBL18548607

SCHEMBL18548607

COc1ccc2c(c1)sc1nc(C(=O)Nc3ccc(-c4cccnc4)cn3)cn12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABCB1 P08183 2/20 0.51
▸ ABCC1 P33527 2/20 0.51
▸ TP53 P04637 4/20 0.49
▸ MAPT P10636 3/20 0.49
▸ SMN1; SMN2 Q16637 3/20 0.49
▸ LMNA P02545 2/20 0.49
▸ RAB9A P51151 2/20 0.49
▸ TSHR P16473 1/20 0.49
▸ ATM Q13315 1/20 0.49
▸ TDP1 Q9NUW8 1/20 0.49
▸ RXFP1 Q9HBX9 1/20 0.47
▸ APP P05067 1/20 0.46
▸ IRAK4 Q9NWZ3 3/20 0.46
▸ THRB P10828 1/20 0.46
▸ PTK2B Q14289 1/20 0.44
▸ SCD O00767 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ USP2 O75604 1/20 0.43
▸ POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29660193 1.00 ABCB1 (0.51) ABCB1ABCC1TP53MAPTSMN1; SMN2
SCHEMBL23053052 0.92 TP53 (0.57) TP53MAPTSMN1; SMN2LMNARAB9A
SCHEMBL18548614 0.87 MAPT (0.50) TP53MAPTSMN1; SMN2LMNARAB9A
SCHEMBL29660157 0.87 MAPT (0.50) TP53MAPTSMN1; SMN2LMNARAB9A
SCHEMBL18548604 0.85 MAPT (0.53) TP53MAPTSMN1; SMN2LMNARAB9A
SCHEMBL18548705 0.85 BRAF (0.53) ABCB1ABCC1SMN1; SMN2
SCHEMBL29660155 0.85 MAPT (0.53) TP53MAPTSMN1; SMN2LMNARAB9A
SCHEMBL29660178 0.85 BRAF (0.53) ABCB1ABCC1SMN1; SMN2
SCHEMBL18548642 0.85 RAB9A (0.52) TP53MAPTSMN1; SMN2LMNARAB9A
SCHEMBL29660319 0.85 RAB9A (0.52) TP53MAPTSMN1; SMN2LMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP claimed
US-10765764-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2020-09-08 — — US claimed
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2019-06-06 — — US claimed
US-10137211-B2 Probes for imaging Huntingtin protein CHDI FOUNDATION, INC. (US) 2018-11-27 — — US claimed
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-03-02 — — US claimed
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF CHDI FOUNDATION, INC. 2022-12-29 — — US disclosed
US-11389438-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2022-07-19 — — US disclosed
US-11344637-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2022-05-31 — — US disclosed
US-11344637-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2022-05-31 — — US disclosed
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP disclosed
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2021-03-04 — — US disclosed
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2021-03-04 — — US disclosed
US-10765764-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2020-09-08 — — US disclosed
US-20200276176-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF CHDI FOUNDATION, INC. 2020-09-03 — — US disclosed
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2019-06-06 — — US disclosed
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2019-06-06 — — US disclosed
US-10137211-B2 Probes for imaging Huntingtin protein CHDI FOUNDATION, INC. (US) 2018-11-27 — — US disclosed
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-03-02 — — US disclosed
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-03-02 — — US disclosed
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-03-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11344637-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 ABCB1 2577/4885ABCC1 1113/4885TP53 741/4885
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 ABCB1 2577/4885ABCC1 1113/4885TP53 741/4885
US-11389438-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 ABCB1 2615/4885ABCC1 2107/4885TP53 42/4885
US-20200276176-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF HTT, HYPK, UBQLN2 ABCB1 2615/4885ABCC1 2107/4885TP53 42/4885
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 ABCB1 2577/4885ABCC1 1113/4885TP53 741/4885
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 ABCB1 2577/4885ABCC1 1113/4885TP53 741/4885
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF HTT, HYPK, UBQLN2 ABCB1 2615/4885ABCC1 2107/4885TP53 42/4885
US-10765764-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 ABCB1 2577/4885ABCC1 1113/4885TP53 741/4885
US-10137211-B2 Probes for imaging Huntingtin protein HTT, HYPK, FABP7 ABCB1 2501/4885ABCC1 1249/4885TP53 642/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.