Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 7/20 | 0.36 |
| ▸ | CSF1R | P07333 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
| ▸ | MUSK | O15146 | 1/20 | 0.36 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29660126 | 0.87 | MAPT (0.47) | LMNARXFP1APPFLT3TP53 | |
| SCHEMBL18548691 | 0.87 | MAPT (0.47) | LMNARXFP1APPFLT3TP53 | |
| SCHEMBL18548695 | 0.79 | FLT3 (0.51) | LMNAFLT3CSF1RRETPDGFRB | |
| SCHEMBL29660211 | 0.79 | TP53 (0.43) | HSD17B10LMNAAPPTP53MAPT | |
| SCHEMBL18548699 | 0.79 | TP53 (0.43) | HSD17B10LMNAAPPTP53MAPT | |
| SCHEMBL18548629 | 0.76 | MAPT (0.53) | HSD17B10LMNAAPPIRAK4TP53 | |
| SCHEMBL29660143 | 0.76 | MAPT (0.53) | HSD17B10LMNAAPPIRAK4TP53 | |
| SCHEMBL18548725 | 0.74 | GRM5 (0.36) | LMNARXFP1FLT3CSF1RRET | |
| SCHEMBL29660157 | 0.73 | MAPT (0.50) | LMNARXFP1APPFLT3TP53 | |
| SCHEMBL18548708 | 0.70 | MAPT (0.47) | LMNARXFP1APPFLT3TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3340796-B1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION INC (US) | 2021-04-21 | — | — | EP | claimed |
| US-10765764-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2020-09-08 | — | — | US | claimed |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2019-06-06 | — | — | US | claimed |
| US-10137211-B2 | Probes for imaging Huntingtin protein | CHDI FOUNDATION, INC. (US) | 2018-11-27 | — | — | US | claimed |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2017-03-02 | — | — | US | claimed |
| US-12083108-B2 | Compounds for targeting mutant huntingtin protein and uses thereof | CHDI FOUNDATION, INC. (US) | 2024-09-10 | — | — | US | disclosed |
| US-20220409600-A1 | COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF | CHDI FOUNDATION, INC. | 2022-12-29 | — | — | US | disclosed |
| US-11389438-B2 | Compounds for targeting mutant huntingtin protein and uses thereof | CHDI FOUNDATION, INC. (US) | 2022-07-19 | — | — | US | disclosed |
| US-11344637-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-11344637-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| EP-3340796-B1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION INC (US) | 2021-04-21 | — | — | EP | disclosed |
| EP-3340796-B1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION INC (US) | 2021-04-21 | — | — | EP | disclosed |
| US-20200276176-A1 | COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF | CHDI FOUNDATION, INC. | 2020-09-03 | — | — | US | disclosed |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2019-06-06 | — | — | US | disclosed |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2019-06-06 | — | — | US | disclosed |
| US-10137211-B2 | Probes for imaging Huntingtin protein | CHDI FOUNDATION, INC. (US) | 2018-11-27 | — | — | US | disclosed |
| WO-2017040336-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2017-03-09 | — | — | WO | disclosed |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2017-03-02 | — | — | US | disclosed |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2017-03-02 | — | — | US | disclosed |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2017-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11344637-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | HSD17B10 966/4885CHRNB2 1624/4885CHRNB4 2549/4885 |
| US-12083108-B2 | Compounds for targeting mutant huntingtin protein and uses thereof | HTT, HYPK, UBQLN2 | HSD17B10 2464/4885CHRNB2 2271/4885CHRNB4 2752/4885 |
| US-11389438-B2 | Compounds for targeting mutant huntingtin protein and uses thereof | HTT, HYPK, UBQLN2 | HSD17B10 2464/4885CHRNB2 2271/4885CHRNB4 2752/4885 |
| US-20200276176-A1 | COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF | HTT, HYPK, UBQLN2 | HSD17B10 2464/4885CHRNB2 2271/4885CHRNB4 2752/4885 |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | HSD17B10 966/4885CHRNB2 1624/4885CHRNB4 2549/4885 |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | HSD17B10 966/4885CHRNB2 1624/4885CHRNB4 2549/4885 |
| US-20220409600-A1 | COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF | HTT, HYPK, UBQLN2 | HSD17B10 2464/4885CHRNB2 2271/4885CHRNB4 2752/4885 |
| US-10765764-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | HSD17B10 966/4885CHRNB2 1624/4885CHRNB4 2549/4885 |
| US-10137211-B2 | Probes for imaging Huntingtin protein | HTT, HYPK, FABP7 | HSD17B10 1251/4885CHRNB2 1061/4885CHRNB4 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.