Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29660211 | 1.00 | TP53 (0.43) | TP53MAPTLMNATSHRRAB9A | |
| SCHEMBL18548629 | 0.86 | MAPT (0.53) | TP53MAPTLMNATSHRRAB9A | |
| SCHEMBL29660143 | 0.86 | MAPT (0.53) | TP53MAPTLMNATSHRRAB9A | |
| SCHEMBL11222988 | 0.85 | HSD17B10 (0.56) | TP53MAPTLMNATSHRRAB9A | |
| SCHEMBL17621065 | 0.82 | SRD5A2 (0.49) | TP53MAPTLMNATSHRRAB9A | |
| SCHEMBL17620857 | 0.81 | TP53 (0.64) | TP53MAPTLMNATSHRRAB9A | |
| SCHEMBL18548623 | 0.79 | HSD17B10 (0.41) | TP53MAPTLMNASMN1; SMN2POLB | |
| SCHEMBL17620980 | 0.78 | TP53 (0.46) | TP53MAPTLMNATSHRRAB9A | |
| SCHEMBL11222994 | 0.75 | HSD17B10 (0.48) | TP53MAPTTSHRSMN1; SMN2KDM4E | |
| SCHEMBL17621078 | 0.75 | TP53 (0.43) | TP53MAPTLMNATSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11344637-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| US-11344637-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2022-05-31 | — | — | US | disclosed |
| EP-3340796-B1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION INC (US) | 2021-04-21 | — | — | EP | disclosed |
| EP-3340796-B1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION INC (US) | 2021-04-21 | — | — | EP | disclosed |
| US-20210060187-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-03-04 | — | — | US | disclosed |
| US-20210060187-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-03-04 | — | — | US | disclosed |
| US-10765764-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10765764-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2019-06-06 | — | — | US | disclosed |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2019-06-06 | — | — | US | disclosed |
| US-10137211-B2 | Probes for imaging Huntingtin protein | CHDI FOUNDATION, INC. (US) | 2018-11-27 | — | — | US | disclosed |
| WO-2017040336-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2017-03-09 | — | — | WO | disclosed |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2017-03-02 | — | — | US | disclosed |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2017-03-02 | — | — | US | disclosed |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2017-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11344637-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | TP53 741/4885MAPT 8/4885LMNA 2021/4885 |
| US-20210060187-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | TP53 741/4885MAPT 8/4885LMNA 2021/4885 |
| US-20190167821-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | TP53 741/4885MAPT 8/4885LMNA 2021/4885 |
| US-20170056535-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | TP53 741/4885MAPT 8/4885LMNA 2021/4885 |
| US-10765764-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | TP53 741/4885MAPT 8/4885LMNA 2021/4885 |
| US-10137211-B2 | Probes for imaging Huntingtin protein | HTT, HYPK, FABP7 | TP53 642/4885MAPT 5/4885LMNA 1600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.