Sugi Predict

Sugi Predict / Compounds / SCHEMBL18548739

SCHEMBL18548739

SCHEMBL18548739

COc1ccc2c(c1)sc1nc(C(=O)Nc3ccc(OC)nc3)cn12

nearest known ligand 0.54

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.54
▸ RXFP1 Q9HBX9 1/20 0.54
▸ APP P05067 1/20 0.52
▸ BUB1 O43683 1/20 0.49
▸ MAPT P10636 4/20 0.47
▸ RAB9A P51151 4/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ TP53 P04637 2/20 0.47
▸ TSHR P16473 1/20 0.47
▸ ATM Q13315 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ KMT2A Q03164 1/20 0.47
▸ FLT3 P36888 1/20 0.46
▸ THRB P10828 2/20 0.45
▸ KDM4E B2RXH2 1/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ RECQL P46063 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29660182 1.00 LMNA (0.54) LMNARXFP1APPBUB1MAPT
SCHEMBL29660208 0.90 LMNA (0.54) LMNARXFP1APPMAPTRAB9A
SCHEMBL18548664 0.90 LMNA (0.54) LMNARXFP1APPMAPTRAB9A
SCHEMBL18548663 0.90 MEN1 (0.49) LMNARXFP1BUB1MAPTRAB9A
SCHEMBL29660161 0.90 MEN1 (0.49) LMNARXFP1BUB1MAPTRAB9A
SCHEMBL18548643 0.89 LMNA (0.53) LMNARXFP1APPMAPTRAB9A
SCHEMBL29660176 0.89 LMNA (0.53) LMNARXFP1APPMAPTRAB9A
SCHEMBL18548585 0.89 APP (0.53) LMNARXFP1APPMAPTRAB9A
SCHEMBL18618288 0.89 LMNA (0.53) LMNARXFP1APPMAPTRAB9A
SCHEMBL29660129 0.89 APP (0.53) LMNARXFP1APPMAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP claimed
US-10765764-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2020-09-08 — — US claimed
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2019-06-06 — — US claimed
US-10137211-B2 Probes for imaging Huntingtin protein CHDI FOUNDATION, INC. (US) 2018-11-27 — — US claimed
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF CHDI FOUNDATION, INC. 2022-12-29 — — US disclosed
US-11389438-B2 Compounds for targeting mutant huntingtin protein and uses thereof CHDI FOUNDATION, INC. (US) 2022-07-19 — — US disclosed
US-11344637-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2022-05-31 — — US disclosed
US-11344637-B2 Probes for imaging huntingtin protein CHDI FOUNDATION, INC. (US) 2022-05-31 — — US disclosed
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP disclosed
EP-3340796-B1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION INC (US) 2021-04-21 — — EP disclosed
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2021-03-04 — — US disclosed
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2021-03-04 — — US disclosed
US-20200276176-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF CHDI FOUNDATION, INC. 2020-09-03 — — US disclosed
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2019-06-06 — — US disclosed
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2019-06-06 — — US disclosed
US-10137211-B2 Probes for imaging Huntingtin protein CHDI FOUNDATION, INC. (US) 2018-11-27 — — US disclosed
WO-2017040336-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. (US) 2017-03-09 — — WO disclosed
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-03-02 — — US disclosed
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-03-02 — — US disclosed
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI FOUNDATION, INC. 2017-03-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11344637-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 LMNA 2021/4885RXFP1 660/4885APP 270/4885
US-20210060187-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 LMNA 2021/4885RXFP1 660/4885APP 270/4885
US-11389438-B2 Compounds for targeting mutant huntingtin protein and uses thereof HTT, HYPK, UBQLN2 LMNA 3285/4885RXFP1 4566/4885APP 271/4885
US-20200276176-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF HTT, HYPK, UBQLN2 LMNA 3285/4885RXFP1 4566/4885APP 271/4885
US-20190167821-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 LMNA 2021/4885RXFP1 660/4885APP 270/4885
US-20170056535-A1 PROBES FOR IMAGING HUNTINGTIN PROTEIN HTT, HYPK, HSPBP1 LMNA 2021/4885RXFP1 660/4885APP 270/4885
US-20220409600-A1 COMPOUNDS FOR TARGETING MUTANT HUNTINGTIN PROTEIN AND USES THEREOF HTT, HYPK, UBQLN2 LMNA 3285/4885RXFP1 4566/4885APP 271/4885
US-10765764-B2 Probes for imaging huntingtin protein HTT, HYPK, HSPBP1 LMNA 2021/4885RXFP1 660/4885APP 270/4885
US-10137211-B2 Probes for imaging Huntingtin protein HTT, HYPK, FABP7 LMNA 1600/4885RXFP1 727/4885APP 213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.