Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4191521 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7197280 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28736750 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL502325 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL17941188 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3408939 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL14574834 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL841663 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL23062790 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20607531 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118610487-B | Oxygen reduction catalyst with controllable hierarchical pore structure, and preparation method and application thereof | 佛山仙湖实验室 | 2025-04-08 | — | — | CN | claimed |
| CN-115889680-B | Curing agent for moisture absorption resistant inorganic phosphate binder dry precoated sand and application thereof | 湖北工业大学 | 2025-04-01 | — | — | CN | claimed |
| CN-118610487-A | Oxygen reduction catalyst with controllable hierarchical pore structure, and preparation method and application thereof | 佛山仙湖实验室 | 2024-09-06 | — | — | CN | claimed |
| CN-116478471-A | Flame-retardant polypropylene material and preparation method thereof | 广东甲乙新材料有限责任公司 | 2023-07-25 | — | — | CN | claimed |
| CN-116285190-A | Flame-retardant masterbatch and high-impact-resistance flame-retardant polymer material | 广东甲乙新材料有限责任公司 | 2023-06-23 | — | — | CN | claimed |
| CN-115889680-A | Curing agent for anti-moisture-absorption inorganic phosphate binder dry precoated sand and application thereof | 湖北工业大学 | 2023-04-04 | — | — | CN | claimed |
| CN-111013583-A | Preparation method of monolithic catalyst for efficiently decomposing carbon monoxide at room temperature | 萍乡学院 | 2020-04-17 | — | — | CN | claimed |
| US-20190282475-A1 | High-Performance Hair Treatment Agents With A Proteolipid And A Magnesium Salt | HENKEL AG & CO. KGAA (DE) | 2019-09-19 | — | — | US | claimed |
| US-20170056305-A1 | HIGH-PERFORMANCE HAIR TREATMENT AGENTS WITH A PROTEOLIPID AND A MAGNESIUM SALT | HENKEL AG & CO. KGAA (DE) | 2017-03-02 | — | — | US | claimed |
| CN-102952931-B | Glass-film-free oriented silicon steel manufacture method and annealing isolation agent | BAOSHAN IRON & STEEL CO., LTD. (CN) | 2014-10-29 | — | — | CN | claimed |
| CN-103114181-A | Coating formula of oriented silicon steel barrier coat | GUANGDONG YINGQUAN STEEL PRODUCTS CO LTD | 2013-05-22 | — | — | CN | claimed |
| CN-102952931-A | Glass-film-free oriented silicon steel manufacture method and annealing isolation agent | BAOSHAN IRON & STEEL | 2013-03-06 | — | — | CN | claimed |
| CN-102253166-A | Method for determining activity degree curve of magnesium oxide citric acid for electrical steel | SHOUGANG CO LTD | 2011-11-23 | — | — | CN | claimed |
| WO-2025073885-A1 | COMPOSITION FOR USE IN PATIENTS WITH ILEOSTOMY | AARHUS UNIVERSITET (DK) | 2025-04-10 | — | — | WO | disclosed |
| CN-115889680-B | Curing agent for moisture absorption resistant inorganic phosphate binder dry precoated sand and application thereof | 湖北工业大学 | 2025-04-01 | — | — | CN | disclosed |
| CN-115889680-B | Curing agent for moisture absorption resistant inorganic phosphate binder dry precoated sand and application thereof | 湖北工业大学 | 2025-04-01 | — | — | CN | disclosed |
| CN-102253166-A | Method for determining activity degree curve of magnesium oxide citric acid for electrical steel | SHOUGANG CO LTD | 2011-11-23 | — | — | CN | disclosed |
| CN-102253166-A | Method for determining activity degree curve of magnesium oxide citric acid for electrical steel | SHOUGANG CO LTD | 2011-11-23 | — | — | CN | disclosed |
| CN-102253166-A | Method for determining activity degree curve of magnesium oxide citric acid for electrical steel | SHOUGANG CO LTD | 2011-11-23 | — | — | CN | disclosed |
| CN-201027172-Y | Magnesium carbonate suspending sorting kiln | WANG YUANSHENG HAICHENG HOUYIN (CN) | 2008-02-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170056305-A1 | HIGH-PERFORMANCE HAIR TREATMENT AGENTS WITH A PROTEOLIPID AND A MAGNESIUM SALT | SRRM2, PLP2, KRT18 | MEN1 1264/4885ALDH1A1 4855/4885HMGCR 721/4885 |
| US-20190282475-A1 | High-Performance Hair Treatment Agents With A Proteolipid And A Magnesium Salt | SRRM2, PLP2, KRT18 | MEN1 1264/4885ALDH1A1 4855/4885HMGCR 721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.