Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4191521 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL7197280 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28736750 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL502325 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL17941188 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL14574834 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL841663 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL18548768 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL23062790 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20607531 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147076-A1 | HIGH CONCENTRATION NANOPARTICLE SIZE MAGNESIUM FUEL ADDITIVE FOR FOSSIL FUEL BURNING APPARATUS | PECK WAYNE (KR) | 2008-12-04 | — | — | WO | claimed |
| CN-101314744-A | Nano-particle size magnesium fuel additive composition for fossil fuel combustion device and process for mixing with fossil fuel | PECK WAYNE (US) | 2008-12-03 | — | — | CN | claimed |
| CN-120037918-A | Preparation method and application of iron-cobalt composite carbon-based electrode material | 河南农业大学 | 2025-05-27 | — | — | CN | disclosed |
| CN-113475715-A | Enteral nutrition composition and preparation method and application thereof | 范师振 | 2021-10-08 | — | — | CN | disclosed |
| EP-2259773-B1 | MACROLIDE COMPOSITIONS HAVING IMPROVED TASTE AND STABILITY | PARI PHARMA GMBH (DE) | 2013-07-17 | — | — | EP | disclosed |
| EP-2259773-A1 | MACROLIDE COMPOSITIONS HAVING IMPROVED TASTE AND STABILITY | PARI Pharma GmbH (DE) | 2010-12-15 | — | — | EP | disclosed |
| US-20090232744-A1 | Macrolide compositions having improved taste and stability | PARI PHARMA GMBH (DE) | 2009-09-17 | — | — | US | disclosed |
| WO-2009109390-A1 | MACROLIDE COMPOSITIONS HAVING IMPROVED TASTE AND STABILITY | PARI PHARMA GMBH (DE) | 2009-09-11 | — | — | WO | disclosed |
| WO-2008147076-A1 | HIGH CONCENTRATION NANOPARTICLE SIZE MAGNESIUM FUEL ADDITIVE FOR FOSSIL FUEL BURNING APPARATUS | PECK WAYNE (KR) | 2008-12-04 | — | — | WO | disclosed |
| CN-101314744-A | Nano-particle size magnesium fuel additive composition for fossil fuel combustion device and process for mixing with fossil fuel | PECK WAYNE (US) | 2008-12-03 | — | — | CN | disclosed |